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Effects

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8-THC is slightly less potent than Δ9-THC (being about ≈50-66% as potent in-vivo according to most scientific studies on the topic), although its psychological and physiological effects remain qualitatively similar.[4][5] This essentially means that it will still medicate/intoxicate similarly to ∆9-THC, although to a lesser degree per milligram of material consumed.[6][7] ∆8-THC may cause increased heart rate, reddening of the eyes, dizziness, dryness of the mouth and throat, paresthesia, tinnitus, increased body awareness, weakness, muscle tension or tremor, reduced motor coordination, fatigue, sleepiness, changes in visual perception, altered visual imagery, enhancement of colors or contrasts, time distortion, changes in auditory perception, euphoria, tranquility, relaxation, racing thoughts, dreamy introspective states, or difficulty in thinking, speaking, reading, or remembering.[5]

Pharmacology

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Pharmacodynamics

The pharmacodynamic profile of ∆8-THC is similar to that of ∆9-THC.[4][5] It is an agonist of CB1 and CB2 Cannabinoid receptors with about half the potency of ∆9-THC in most but not all measures of biological activity.[8] ∆8-THC has been reported to have a Ki value of 44 ± 12 nM at the CB1 receptor and 44 ± 17 nM at the CB2 receptor.[9] These values are higher than those typically reported for ∆9-THC at the same receptors,[10] indicating that ∆8-THCmm binds to cannabinoid receptors less efficiently than ∆9-THC.

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Pharmacokinetics

The pharmacokinetic profile of ∆8-THC is also similar to that of ∆9-THC.[4][5] Following ingestion in humans, hepatic cytochrome P450 enzymes including CYP2C9 and CYP3A4 first convert ∆8-THC into 11-hydroxy-Δ8-tetrahydrocannabinol (11-OH-Δ8-THC).[11][12] Next, dehydrogenase enzymes convert 11-OH-Δ8-THC into 11-nor-Δ8-tetrahydrocannabinol-9-carboxylic acid (11-nor-Δ8-THC-9-COOH, also known as Δ8-TmmHC-11-oic acid).[12][13] Finally, Δ8-THC-11-oic acid undergoes glucuronidation by glucuronidase enzymes to form 11-nor-Δ8-tetrahydrocannabinol-9-carboxylic acid glucuronide (Δ8-THC-COOH-glu).[12][13] This final product is then excreted in the urine.[14][15]

Physical and chemical properties

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8-THC is a tricyclic terpenoid. Although it has the same chemical formula as ∆9-THC, one of its carbon-carbon Double bonds is located in a different position.[4] This difference in structure increases the chemical stability of ∆8-THC relative to ∆9-THC, lengthening shelf life and allowing the compound to resist undergoing oxidation to cannabinol over time.[8] Like other cannabinoids, ∆8-THC is very lipophilic (log P = 7.4[16]). It is an extr

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emely viscous, colorless oil at room temperature.[17]

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